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These effects are typically most noticeable when starting treatment or increasing doses and generally diminish over time as your body adjusts

Concept of Off-Label Dosing Off-label dosing refers to the practice of using a medication in a way that differs from the FDAs approved packaging label

In the SURMOUNT-1 trial, tirzepatide showed significant weight loss results in adults without diabetes over 72 weeks (15-21% body weight reduction, depending on dose), while orlistat typically produces more modest results (approximately 3-5% additional weight loss beyond placebo at 1 year)

doi:10.1016/s0378-8741(01)00234-3 Lee YS, Yang WK, Kim HY, et al