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Assuming the results of the ongoing trials are positive, GLP-1 agonists will quickly become an essential addition to the growing armamentarium of therapeutics for patients with psoriasis, especially for those who are obese and have type 2 diabetes

Most of the 316 participants in these studies said that their cravings diminished, meals felt more satiating, and it became simpler to say no to seconds

44 Due to these promising results, as well as its established cardiovascular safety, 42,45 investigational interest around this agent is intense, with multiple randomized trials exploring its effects on liver fibrosis and steatosis of diabetic and nondiabetic patients, when administered alone, in combination or in comparison with other agents, such as empagliflozin (on diabetics-NCT04639414), efinopegdutide (on diabetics and non-diabetics-NCT04944992), cilofexor and firsocostat (on diabetics and non-diabetics-NCT04971785)