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We were now officially their parents. Losing weight had turned Dustins life around, but he knew he needed to make significant changes to keep the weight off for good

Ridha Z et al, Aesthetic Surgery Journal 44(11):NP809-NP818, PMID 38874170) describes GLP-1 receptors on adipose-derived stem cells (ADSCs) and fibroblasts in skin, and proposes that activation of these receptors may reduce protective cytokine production from ADSCs, increase oxidative stress on neighboring fibroblasts, reduce ATP production through altered glucose uptake, and indirectly reduce local estrogen production from dermal white adipose tissue

And for everyone, important signs include symptoms like a decrease in libido, low energy, change in body composition and difficulty maintaining erections