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6-gingerol ameliorates metabolic disorders by inhibiting hypertrophy and hyperplasia of adipocytes in high-fat-diet induced obese mice

Although the SAVOR and EXAMINE studies were delineated to verify cardiovascular safety of two DPP-4i, namely saxagliptin and alogliptin, respectively, both are considered to be the first controlled clinical trials to address the effect of GLP-1 system on CVD

In mice, GLP-1 RA treatment also showed to inhibit the differentiation of T helper (Th) cells into Th1 and Th17 subsets and reduce the release of related proinflammatory cytokines, including IFN-y, TNF-, and IL-17
