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Description
Since tirzepatide may slow gastric emptying as part of its mechanism of action, patients with pre-existing severe gastroparesis could experience worsening of symptoms, including nausea, vomiting, and potential complications related to delayed gastric emptying
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The peptide component differs: tirzepatide is a dual GIP/GLP-1 receptor agonist (39 amino acids), while retatrutide adds a third receptor target the glucagon receptor making it a triple agonist
Understanding tirzepatide's pharmacology is essential for both clinicians and patients to optimize therapeutic outcomes while minimizing potential adverse effects
