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Based on current clinical trial data, tirzepatide (Zepbound/Mounjaro) at the 15 mg dose produces the highest average weight loss approximately 2022% of body weight, or around 48 lbs on average in the SURMOUNT-1 trial
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Quick Comparison# Mechanism of Action Comparison# Semaglutide# Semaglutide is a 31-amino acid GLP-1 receptor agonist with a C18 fatty diacid modification that enables albumin binding and a 7-day half-life

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