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Semaglutide Dosing Semaglutide also follows a weekly injection protocol , but with a slightly different titration process: Starting dose: 0.25 mg weekly (for 4 weeks) Titrated to 0.5 mg weekly , then 1 mg weekly For obesity (Wegovy), doses can be escalated to 2.4 mg weekly Rybelsus offers a daily oral tablet option (7 mg or 14 mg), though weight loss outcomes are not as pronounced as with the injectable formulations Injection vs Oral Options The availability of oral Semaglutide (Rybelsus) makes it unique, particularly for individuals who prefer not to self-inject