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Relative to placebo, tirzepatide was also associated with significant improvements in BMI, HbA1c, fasting glucose, fasting insulin, lipid levels, and systolic and diastolic pressure, which emphasizes the need to continue pharmacotherapy to prevent weight regain and ensure the maintenance of cardiometabolic benefits (Aronne et al

In light of the substantial in vivo and in vitro evidence supporting the efficacy of GLP-1 RAs, further research into their protective mechanisms is imperative

35,36 Overall, these studies did not show a significant change in urine potassium concentration

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