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It appears that only in RYGB and SG patients intestinal derived GLP-1 has a true endocrine role, while in healthy individuals, localized, paracrine and neuronal signals primarily define the GLP-1 physiology

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Clinical trial data demonstrate that injectable semaglutide generally produces greater reductions in both HbA1c and body weight compared to the oral formulation, though both forms show clinically meaningful benefits

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Integrin v1 inhibitor (a small molecule, PLN-1474) is in a Phase 1 trial for MASH fibrosis (Slack et al

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"Mensen hebben nauwelijks trek in voedsel waardoor ze in korte tijd spectaculair veel kunnen afvallen" Als GLP-1-receptoragonisten of semaglutide als afvalmiddel worden gebruikt, is het voordeel dat het inderdaad goed en snel werkt en dat mensen nauwelijks trek hebben in voedsel

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