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Description
This is a different approach entirely, combining a GLP-1 agonist with an amylin receptor agonist rather than adding GIP or glucagon
The promise: better weight loss, greater metabolic benefits
The dosing protocols differ significantly between the two medications, with tirzepatide starting at 2.5 mg weekly and potentially escalating to 15 mg based on tolerance and response
The main Phase 3 dose steps include 2mg, 4mg, 6mg, 9mg and 12mg, with 12mg being the highest dose currently studied in major obesity trials
