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Description
27,28 GLP-1 receptor agonists (GLP-1 RAs) have been developed for the treatment of metabolic disorders, including obesity and type 2 diabetes (T2D)

[7-9] For sitagliptin, no differences in cardiac events were observed compared with placebo in an analysis of 5,429 patients, [7] and similar results were found for vildagliptin against all comparators in data from 7,509 patients

was supported by funding from the European Research Council (ERC)-AdG HypoFlam grant (695054)

124,125,126 The design concept of these multi-agonists is to simultaneously regulate multiple key metabolic pathways to achieve more effective control over blood sugar, body weight, and overall metabolic health