is jardiance a glp 1 drug Eli Lilly, Boehringer hit FDA roadblock in quest to repurpose for Type diabetes SGLT2 vs GLP-1 for CKD:
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Campbell JE, Drucker DJ (2013) Pharmacology, physiology, and mechanisms of incretin hormone action

The 18% discontinuation rate at the highest dose means roughly 1 in 5 people cannot tolerate retatrutide at maximum dose

Tapering off is when you slowly lower your dose or stretch out your dose frequency
JAMA Intern Med 176 , 14741481 (2016)
