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Unfortunately, numerous psychotropic medications can increase weight and appetite due to a variety of mechanisms, including antihistaminergic effects, direct appetite-stimulating effects, and proclivities to cause insulin resistance

The mechanism by which Epac inhibits the NHE3 transporter has not been determined (Carraro-Lacroix et al., 2009)

Continued surges in GLP-1 agonist prescriptions are expected, so clinicians that provide sedation/anaesthesia services must understand and account for the unique anaesthetic risks for these patients

[7] It is important to note that people with type 2 diabetes already have an elevated baseline risk of pancreatitis compared to the general populationapproximately two to three times higherdue to shared risk factors including obesity, hypertriglyceridaemia, and metabolic dysfunction