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PMID: 33760905 Aroda VR et al (2016): Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

Now, thats not a precise number, its a best guess from the research currently available
Sam Berkman, clinical professor of medicine at UCLA, explains why orthopedic surgery is a risk factor for blood clots and how patients can protect themselves from this potentially fatal complication

This was supported by protein changes indicating enhanced immune modulation and cellular detoxification
