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p , Representative image of injection site in NTS after injection of Cre-dependent AAV2.2-DIO-ChR2-EYFP in NTS GLP1R neurons in Glp1r-ires-Cre mice (n = 3 mice)

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Key findings: 29% reduction in coronary heart disease death, myocardial infarction, or ischemic stroke (3-point MACE) 21% reduction in broader cardiovascular events including revascularization (4-point MACE) Median LDL-C reduced to 45 mg/dL versus 106 mg/dL with placebo Benefits were consistent regardless of concomitant GLP-1 receptor agonist or SGLT2 inhibitor use

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