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People respond differently, and some achieve excellent weight loss results without significant GI symptoms

This uncoupling is clinically relevant because it suggests the bone density changes seen in the Hansen trial are not simply a transient effect of weight loss but may reflect a direct or indirect metabolic effect of GLP-1 receptor activation on bone turnover

How those ingredients compare to prescription GLP-1 medications in terms of real-world effectiveness

For patients outside that profile, it is an impractical choice not a bad product, but the wrong product for their situation
