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The preventative benefits seem to be facilitated by reduced lipogenesis, increased autophagy, enhanced insulin signalling, and regulation of the FXR/RXR and LXR/RXR pathways (Ma et al

In addition, mild to moderate gastrointestinal side effects were more frequent in the semaglutide-treated group compared to the placebo-treated group

25 To a lesser extent, this same phenomenon has been reported in studies of aggressively treated type 2 diabetic patients and in obese diabetic patients treated with bariatric surgery that resulted in a lowering of hemoglobin A1c along with weight loss