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Optimizing thyroid hormone dosing first creates a metabolic foundation that allows GLP-1 benefits to become apparent
When Ozempic was approved for type 2 diabetes in 2017, people and clinicians started noticing something different: the once-weekly dose was easier to stick with, and many people were losing a meaningful amount of weight even though that wasnt its main purpose

By this point, your body has already adapted to two months of tirzepatide exposure

Acknowledgements We thank Dr Serge Luquet, Giuseppe Gangarossa, Nicolas Thiebaud and Claire Martin for their advice and helpful discussions