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Taken together, with the overlap between OA risk factors and the metabolic syndrome, the demonstrated anti-inflammatory activities of GLP-1 in several tissues [10] and the expression of GLP-1R in joint tissues, GLP-1 analogues may be good therapeutic candidates for treating OA
Beyond the quick fix that medications provide, patients have a hard time sticking to healthy lifestyle change, and give up if they dont see their hard work pay off

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Weight management with GLP-1 medications is typically an extended process, with clinical trials evaluating outcomes over 64 to 72 weeks
