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Besides the trial sub-population being at severe cardiovascular risk, 72% were male, 84% Caucasian and 66% had A1c levels over 5.7 indicating prediabetes
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The study revealed a 3.3 bpm increase in heart rate in patients taking Wegovy, compared to a 0.8 bpm reduction in the placebo group.
A 2026 study published in The Lancet Obstetrics, Gynaecology & Womens Health found that combining GLP-1 therapy with HRT produced greater mean weight loss than GLP-1 alone in this patient population
