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Semaglutide injections are FDA-approved for chronic weight loss management

Keywords: obesity, pharmacotherapy, glucagon-like peptide-1, obesity management Graphical Abstract Introduction Obesity remains a disease of epidemic proportions, with up to 43% of the United States population affected and rates worldwide doubling from 1990 to 2022.1,2 This rising prevalence of obesity brings significant costs to the healthcare system, estimated to be up to $172 billion in annual expenditures.3 Obesity is a disease of excess adiposity, but the diagnostic criteria remain an area of debate.4 Obesity has traditionally been classified based upon body mass index (BMI), as described in Table 1.5 BMI is a simple and reliable, population-based, metric for measuring body size, but comes with limitations for identifying individuals at increased risk of complications of obesity, particularly within different ethnic groups.6 Additional methods of measuring adiposity are detailed in Table 1

This chronic, low-grade systemic endotoxemia drives the profound fatigue, widespread joint pain, and neuroinflammation that define the daily experience of living with long-term COVID

Most patients find that any initial discomfort is manageable and improves significantly after the first 12 weeks, with the therapeutic benefits becoming more apparent over the following months