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Prior analyses have either used models that exclude the results of cardiovascular outcomes trials (with any reductions in cardiovascular and kidney outcomes being extrapolated only from changes in HbA 1c [13]), considered only specific high-risk populations [45, 46], or modelled the populations used in cardiovascular outcomes trials, which represent only 2060% of all people with type 2 diabetes [14]

Glucagon-like peptide-1 (GLP-1) receptor agonists provide an effective treatment option for obesity-related weight loss

Nat Rev Gastroenterol Hepatol 2020;17:27997

This means it acts on three hormone receptor pathways involved in appetite, fullness, blood sugar control and energy balance