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In RIN 1046-38 cells, the GLP-1-induced rise in insulin mRNA is accompanied by an increased expression of GLUT1 and hexokinase1 [464]

GLP-1, oxyntomodulin and exendin-4, whose affinities are influenced by the presence of G s , promote a more closed bundle relative to exendin-P5, whose affinity is less sensitive to the presence of G s

But BMI is far from perfect and shouldnt be the only consideration
