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Consequently, IL-6/STAT3 signaling is correlated with tumor progression, invasion, and immune evasion [174]
Broader Cancer Outcomes and Mechanistic Insights For most other cancers, recent clinical evidence demonstrates largely positive outcomes, with several meta-analyses showing no excess risk and even a reduced risk for hepatocellular carcinoma and colorectal cancer (relative to insulin users)
These genetic markers reflect metabolic susceptibility, not a guarantee of medication efficacy
