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Some may tolerate semaglutide or tirzepatide better, particularly given retatrutide's higher GI side effect rates and the new dysesthesia safety signal
The mechanism, if it exists, likely relates to the metabolic stress of rapid weight change rather than a direct effect of the peptide itself
After accounting for the results from the interim analysis, the nominal two-sided significance level for the primary outcome was 0.04561
Axios , Insurers push back on GLP-1 coverage (Feb 2025) ( [65] )
