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Some studies report increases of 2 to 3 beats per minute (bpm), yet others, including a Holter electrocardiogram study, found mean increases of 13 bpm (129)

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Another preclinical study found that treatment with 0.1 to 10 nM exendin4 significantly decreased the proliferation of MCF7, MDAMB231, and KPL1 cells in a dosedependent manner

Such hyperandrogenemia has a deleterious impact on ovulation and metabolic function, promoting adiposity and insulin resistance 5
