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When semaglutide activates these receptors, it reduces appetite and food cravings by dampening the brain's reward response to eating

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This dual action means it can: Control appetite even better than single-hormone medications Improve blood sugar control more effectively Lead to greater weight loss in many people Help your body use insulin more efficiently Tirzepatide is sold under the brand names Mounjaro for diabetes and Zepbound for weight loss

Sensitivity analyses using inverse probability of treatment weighting produced very similar results (eFigure 4 and eFigure 6 in Supplement 2)