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In nutrient-replete states, GLP-1induced insulin signaling suppresses adipose lipolysis, whereas during reduced caloric intake and relative glucose scarcity, lipid substrates become the dominant oxidative fuel [59, 60]

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Retatrutide and tirzepatide are innovative medications showing promising potential for weight loss and improving metabolic health, particularly in managing obesity and type 2 diabetes

The New York Times reported that in one clinical trial, 63 percent of patients taking Wegovy showed clearance of fat and inflammation in the liver without worsening of scarring, compared to 34 percent in the placebo group