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did not observe significant differences in amputation risk between GLP-1 receptor agonists, SGLT-2 inhibitors, and other diabetes medications in a large retrospective cohort study of 1,222,436 patients with type 2 diabetes

Lastly, keep in mind that most studies showing efficacy of GLP-1 agonists for weight loss usually require participants to make lifestyle modifications such as changes in diet and exercise, to control portions and eat high nutrient, low energy foods and move more while taking the medications

This could indicate that the GLP-1 receptor agonism successfully counters the acute hyperglycemic effects of glucagon agonism, while chronic glucagon agonism promotes body weight loss and improves in glucose tolerance [29]

Why would they take such a risk