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Sensitivity: 30-min post-injection 66.7%, 60-min post-injection 83.3%, combined 100% and specificity: 30-min post-injection 100%, 60-min post-injection 100%, combined 100%, which was corroborated by the results of in vitro time-based analysis of internalized probe accumulation

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These may be considered for specific patient profiles but often offer less sustained weight loss than semaglutide-based or dual-agonist injectables

While early evidence suggests that dual receptor modulators may offer enhanced metabolic control and potentially greater kidney protection compared to standard GLP-1RAs, further research is needed to establish conclusive outcomes and determine their role in the therapeutic landscape for CKD management