american academy of cardiology glp 1 Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the College Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society - Demystifying GLP-1s

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Objective To determine whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with an increased risk of suicidal ideation, self-harm, and suicide among patients with type 2 diabetes compared with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter-2 (SGLT-2) inhibitors

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Notably, GLP-1RAs benefit pain management through their neuroprotective and metabolic regulatory properties, such as inhibiting inflammation responses and oxidative stress, promoting -endorphin release and modulating several other crucial biological pathways