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Several factors can contribute to insulin resistance, including: Risk factors for prediabetes include: Race and ethnicity are also factors
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[DOI] [PubMed] [Google Scholar] Maskery M, Goulding EM, Gengler S, Melchiorsen JU, Rosenkilde MM, Hlscher C

Starting at a lower dose (e.g., 2 mg instead of 4 mg) helps reduce gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation, which are more common with higher initial doses
