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In summary, ER stress is a critical contributor to testicular dysfunction in diabetes (Fig

They stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is released only when blood glucose levels are elevated

doi: 10.1016/j.clinthera.2011.04.024 [DOI] [PubMed] [Google Scholar] 123.Jyrkas J, Tolonen A
Thus, -arrestin-1 interacts directly with GLP-1R and amplifies GLP-1 signaling and may influence -cell performance and growth