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Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM

Secondary outcome Patients with IBS who were prescribed antidepressants experienced a significantly higher incidence of secondary outcomes, including hypertension, cardiac arrhythmia, inpatient encounters, heart failure, ischemic heart disease, aspiration pneumonitis, falls, stroke, serotonin syndrome, suicidal ideation, gastrointestinal bleeding, and obesity

Incident users were required to have used oral antihyperglycemics as a proxy for T2DM during the pre-index period

Continued use of Semaglutide is typically recommended to maintain weight loss results over the long term