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In addition, cotadutide was shown to be safe and, in common with the GLP-1 analogues, was associated with dose-dependent gastrointestinal adverse events, especially nausea and vomiting [82]

Both medications used alongside lifestyle intervention

31,35-37 Prospective trials are needed to further explore this potential adverse event and worsened DR, which is the central premise of the ophthalmic FOCUS trial that is expected to release results in 2026

Severe gastroparesis cases requiring feeding tubes or permanent dietary restrictions may settle in the $400,000 to $700,000 range, while NAION vision loss claims involving permanent blindness could exceed $1 million due to lifetime disability