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When Lillys coupon program ended in the summer of 2023, McCaskills health-care provider suggested another option: compounded tirzepatide, a version of the drug thats not FDA-approved but which was made available legally through a local pharmacy

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Chronic GLP-1 analog treatment also appears to alter food cue-induced brain activity responses, as 17 days of treatment with liraglutide in diabetic patients is sufficient to reduce insula and putamen responsiveness to highly desirable food cues, in conjunction with a decrease in hunger ratings in response to the food cues [34,35]

STEP 2 also excluded patients with uncontrolled and potentially unstable diabetic retinopathy or maculopathy