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These changes contribute to improved endothelial function, reduced arterial stiffness, and better left ventricular compliance, especially relevant in HFpEF [30]

Factors influencing this decision include: GI sensitivity Blood sugar control needs Medication half-life I personally have seen patients switch without the need for a washout period except for on rare occasions when they experience severe side effects from semaglutide Potential Benefits of Switching to Tirzepatide Potential Benefits of Switching to Tirzepatide Switching from semaglutide to tirzepatide may offer several potential benefits, especially for individuals who havent achieved their target weight or glycemic control

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