mechanism glp 1 receptor agonist GLP-1 Agonists – Peripheral Brain Glucagon-like peptide-1 receptor: mechanisms and

doi: 10.1371/journal.pone.0264974 [DOI] [PMC free article] [PubMed] [Google Scholar] 209.Norgaard RA, Bhatt DK, Jarvinen E, et al

Based on the time effect and injection volume, GLP-1RAs can be categorized as either short-acting or long-acting

From a pharmacokinetic perspective, besides increased gastric emptying, obesity has been suggested to modulate CYP gene expression, and increased fat mass may result in an increased Vd of lipophilic drugs.210,211 The weight loss effects from GLP-1 RA treatment may reverse these changes and alter the pharmacokinetics of co-administered lipophilic drugs by decreasing the Vd (Figure 3)

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