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Hypothyroidism slows metabolism and makes weight loss harder, but GLP-1 receptor agonists like semaglutide can still be effective when thyroid hormone is optimized

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Evidence from experimental and clinical studies indicates that various diets, including Mediterranean, Nordic, Palaeolithic and ketogenic diets, increase insulin sensitivity, decrease gluconeogenesis, and adiposity, and exert anti-inflammatory effects, thus preserving immuno-metabolic homeostasis in individuals with T2D