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In a locomotor activity assay, systemic administration of liraglutide (100 or 200 g/kg, s.c.) dose-dependently reduced cocaine-induced hyperlocomotion (10 mg/kg, i.p.) without altering baseline locomotion

When to Switch From Standard GLP-1 to Dual-Compound or Microdose Protocols If you've lost weight initially but plateaued after 812 weeks, and your hunger has returned despite dose increases, switching to a dual-compound approach may reignite progress

Patients should seek immediate medical attention for severe abdominal pain, persistent vomiting, signs of dehydration, or vision changes (particularly with semaglutide, which carries a diabetic retinopathy warning)

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