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Even so, because of the known side effects, the medication is always started at a low dose and periodically escalated following a fixed schedule, he says
Apart from the combinations of GLP-1RAs with other incretin analogs, it should be highlighted that a GLP-1RA was combined with an FGF-21 analog in a single molecule (GLP-1-Fc-FGF21 D1), yielding encouraging results [48]
Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat
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