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Severe or persistent pain : While mild discomfort is common, severe pain at the injection site that does not improve with over-the-counter analgesics or that interferes significantly with daily activities should be evaluated

The comparison gets even more compelling over time
Also, the drug to be transported must avoid lysosomal compartments to prevent degradation

Arrows indicate the density corresponding to the linker between the NTD and transmembrane bundle, and G lipid moiety inserting into the detergent micelle
