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In 2022, a new drug called Tirzepatide sold under the brand name Mounjaro was approved by the FDA

DiMarchi had just left the company and become a professor of chemistry at Indiana University, and also wanted to develop obesity treatments that combine multiple drug targets

Certain populations should avoid GLP-1 probiotic supplements or use them only under close medical supervision due to elevated risk of adverse outcomes

The first molecules that were developed were based on an exendin-4 backbone which was isolated from the saliva of the Gila monster ( Heloderma suspectum ) which shares 53% homology with GLP-1