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Design, Setting, and Participants In this cohort study, adults with overweight or obesity receiving semaglutide or tirzepatide between May 2022 and September 2023 were identified using electronic health record (EHR) data linked to dispensing information from a collective of US health care systems

In research models, glucagon-receptor activation is associated with increased energy expenditure and hepatic glucose-output modulation effects that GLP-1-only or GLP-1/GIP dual agonists do not produce

Supplementing can help improve fat metabolism and energy levels when combined with weight loss efforts