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While gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation, and abdominal pain) are the most frequently reported side effects, fatigue and asthenia (weakness) are recognized drug-associated effects

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[DOI] [PubMed] [Google Scholar] Lonart G, Schoch S, Kaeser PS, Larkin CJ, Sdhof TC, Linden DJ

Despite rising heterogeneity between the two included studies due to different patient populations, this confirmed the efficacy of retatrutide in diabetics and nondiabetics
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