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GLP-1 receptor agonists in the management of obesity and diabetes

Rule out nutrition, stress, medication interactions

Traditionally used in Chinese and Ayurvedic medicine for gastrointestinal complaints and infections, berberine has gained attention in recent years as a potential supplement for metabolic health, particularly in relation to blood glucose control

Pharmacologically, signaling studies demonstrate that tirzepatide mimics the actions of native GIP at the GIP receptor but shows bias at the GLP-1 receptor to favor cAMP generation over -arrestin recruitment, coincident with a weaker ability to drive GLP-1 receptor internalization compared with GLP-1