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In conclusion, the reason why the ApoE 4 allele increases the risk of developing AD is not because it interacts with amyloid or tau but because of the physiological roles it plays in being less effective in supporting insulin signaling and energy utilization by neurons and in activating the inflammation response more than the other two alleles
Sugiura K, Fujita H, Komine M, Yamanaka K, Akiyama M
Tirzepatide (Mounjaro for diabetes, Zepbound for obesity) produces 15-22.5 percent reductions depending on dose
These can be energy-supporting nutrients like iron or vitamin B12, or probiotics to manage gut health
