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Genetic elimination of K ATP channels ( Kir6.2 / mice) significantly increases glucose absorption and glucose-stimulated GIP secretion, through a compensatory increase in duodenal Sglt1 mRNA expression (Ogata et al., 2014)

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Highlights : Semaglutide has set a new standard for weight loss, with Wegovy often leading to 15% or more body weight reduction in clinical trials
