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Pharmacokinetics: Bioavailability: ~90% Half-life: ~2430 hours Metabolism: Minimal hepatic metabolism Excretion: Mainly renal Adverse Effects: Headache Nausea Abdominal pain Diarrhea Interesting Fact: Unlike older prokinetic agents (like cisapride), prucalopride has high receptor selectivity, reducing the risk of cardiac arrhythmias a major safety improvement

Mice were treated with cotadutide, liraglutide, g1437 or liraglutide+g1437 at equimolar dosing (10 nmol/kg, SC, QD for 42 days) compared to vehicle

PMID 40583149

Diabetes Care 47(10):17181730 Lundgren JR, Janus C, Jensen SBK, Juhl CR, Olsen LM, Christensen RM et al (2021) Healthy weight loss maintenance with Exercise, Liraglutide, or both combined