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Semaglutide has generated significant attention for its ability to promote substantial, sustained weight lossprimarily through its potent appetite-suppressing effects

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Several investigations showed that treatment with GLPs may lead to improvement in dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (Table 1)

5,6 In addition, receptor activator of nuclear factor kappa beta ligand (RANKL), that plays a crucial role in osteoclast activity and bone resorption, 21 also directly influences pancreatic beta-cell function and overall metabolism, with its activity being compromised in obesity and T2D